even if tamoxifen and raloxifene has been approved by the FDA for the prevention of breast cancer, but the side effects are still worrying. Selective estrogen receptor modulators play an important role in reducing estrogen in certain parts of the body, and may play an opposite role in other parts of the body. For example, tamoxifen is estrogen receptor modulators in breast tissues in the uterus and bones but as estrogen receptor agonists, which may increase the risk of uterine cancer or endometrial cancer (although very low). However, for women with a high risk of breast cancer, the drug may be far less harmful than the benefits of prevention.
with age, women are more likely to develop breast cancer, just like heart disease or osteoporosis. Take statins or aspirin can prevent cardiovascular disease, calcium can prevent osteoporosis, a similar drug can prevent breast cancer? Some drugs, such as aromatase inhibitors and selective estrogen receptor modulators can indeed play a preventive effect of breast cancer.
so what are the benefits that women can benefit from preventive medicine? How to pick out high-risk women is a problem. Cholesterol levels and blood pressure can accurately predict the risk of heart disease, so cholesterol lowering drugs can effectively prevent heart disease. In the prevention of breast cancer, there is no such markers of cholesterol. Mutations in the BRCA1 and BRCA2 genes do predict breast cancer risk, but
selective estrogen receptor modulators, most of the breast cancer prevention drugs are tamoxifen. It reduces the risk of breast cancer in women by reducing the effects of estrogen on the body. The United States called "on the prevention of breast cancer clinical trials" found that 5 years of tamoxifen (60 mg daily), can reduce the risk of developing breast cancer in postmenopausal women 50%. The U.S. Food and Drug Administration (FDA) has approved the use of tamoxifen in women at high risk for breast cancer to reduce the risk of breast cancer. Also called a selective estrogen receptor modulator raloxifene, was approved by the FDA for the prevention of breast cancer. In clinical trials, taking raloxifene 25 mg per day, for 5 years, can reduce the risk of female breast cancer 35%.
how to judge who can benefit from it?
aromatase inhibitors can reduce the release of oestrogen to prevent breast cancer. Estrogen not only promote female sexuality development, will promote the growth of breast cancer, and our bodies rely on aromatase to make estrogen, inhibit the aromatase as a fundamental solution to the tumor. Exemestane is the new aromatase inhibitors. The United States over a 3 year trial showed that compared with placebo in women, taking the chance of exemestane of female breast cancer decreased by 65%. At present, more research is confirmed according to the preventive effect of exemestane is sustained, it will bring side effects.
what medicine can prevent breast cancer?